Milestone is a darned good herbicide with good residual control.
My problem weed is Canada thistle. 2,4-D and 2,4-D + dicamba will burn down Canada Thistle but will not kill. Most of my neighbors use HiDep which is just 2,4-D for thistle contol but they are not killing the thistles, they just stunt them. Over several years they may kill them. Our major problem is that we get a lot of weeds seeds in our irrigation water so continuous control is required.
Milestone will do a number on Canada Thistle. Last time I bought some it was $96 a quart BUT I applied it at 1/2 pt per acre and got excellent control. That was two years ago. I need to go out and do it again because the water has brought on more seed. But because of the continual resupply of seed from sources beyond my control I"m not going to use Milestone. I simply cannot afford to use it yearly in my situation.
In your case, if your infestation is a "one of" situation, and if Milestone is on the label for your "weed from H*ll" use it once and be done with it. Be aware if you use the treated ground for grazing, Milestone is not broken down in the digestive tract of grazing animals and the manure, even if composted, will kill broadleaf plants. (See the label.)
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